LHI Member's Recent Accomplishments

LHI Member Activity: February 1, 2023 - April 30, 2023

Emilyn Alejandro, PhD

Publications

Overexpression of Pdx1, reduction of p53, or deletion of CHOP attenuates pancreas hypoplasia in mice with pancreas-specific O-GlcNAc transferase deletion https://pubmed.ncbi.nlm.nih.gov/36623733/
Metformin impairs trophoblast metabolism and differentiation in a dose-dependent manner https://pubmed.ncbi.nlm.nih.gov/37250894/

Grants

R01-Placental Insulin Signaling and mTOR Nutrient-Sensing Programming of Offspring Metabolic Health

Victor Barocas, PhD

Publications

A structural bio-chemo-mechanical model for vascular smooth muscle cell traction force microscopy https://pubmed.ncbi.nlm.nih.gov/37004657/

Other Noteworthy Items

Kayla Lehtola, a Materials Science Ph.D. student working in my lab, received an NSF Graduate Research Fellowship.
Invited seminar at Virginia Tech on Feb 8, 2023.

Alessandro Bartolomucci, PhD

Publications

Contextual modifiers of healthspan, lifespan, and epigenome in mice under chronic social stress https://pubmed.ncbi.nlm.nih.gov/37043532/

Bryce Binstadt, MD, PhD

Publications

Autoimmune Valvular Carditis Requires Endothelial Cell TNFR1 Expression https://pubmed.ncbi.nlm.nih.gov/37021574/

Lin Yee Chen, MD, MS

Publications

Association of abnormal p-wave parameters with brain MRI morphology: The atherosclerosis risk in communities neurocognitive study (ARIC-NCS) https://pubmed.ncbi.nlm.nih.gov/36924350/
Association of Physical Activity With Left Atrial Function in Older Adults: The ARIC Study https://pubmed.ncbi.nlm.nih.gov/36752428/
Circulating Magnesium and Risk of Major Adverse Cardiac Events among Patients with Atrial Fibrillation in the ARIC Cohort https://pubmed.ncbi.nlm.nih.gov/36904210/
Relationship Between High Blood Pressure, Atrial Cardiopathy, and Mortality in the General Population https://pubmed.ncbi.nlm.nih.gov/35861252/
Left Atrial Mechanical Dysfunction and the Risk for Ischemic Stroke in People Without Prevalent Atrial Fibrillation or Stroke : A Prospective Cohort Study. https://pubmed.ncbi.nlm.nih.gov/36534978/

Other Noteworthy Items

Mentee: Dr. Jeremy Van't Hof was awarded an AHA Career Development Award, "Examining Pharmacy Deserts as a Modifiable Risk Factor for Hypertension Control" 4/1/23 - 3/31-26

Daniel Duprez, MD, PhD

Publications

Effect of insulin resistance on CAC scores in cancer survivors https://pubmed.ncbi.nlm.nih.gov/37060010/
Sleep Irregularity and Subclinical Markers of Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis https://pubmed.ncbi.nlm.nih.gov/36789869/
Reproducibility of PTC1 and PTC2, indices of arterial compliance, from the radial artery waveform: The Multi-Ethnic Study of Atherosclerosis https://pubmed.ncbi.nlm.nih.gov/36721317/
The association between arterial compliance, as assessed by PTC1 and PTC2 from radial artery waveforms, and age, sex, and race/ethnicity https://pubmed.ncbi.nlm.nih.gov/37071438/
Inter-arm systolic blood pressure difference: non-persistence and association with incident cardiovascular disease in the Multi-ethnic Study of Atherosclerosis https://pubmed.ncbi.nlm.nih.gov/35296776/
Nontraditional Risk Factors for Progression Through Chronic Kidney Disease Risk Categories: The Coronary Artery Risk Development in Young Adults Study https://pubmed.ncbi.nlm.nih.gov/36565799/
Small dense low-density lipoprotein cholesterol compared to other lipoprotein biomarkers for predicting coronary heart disease among individuals with normal fasting glucose: The Multi-Ethnic Study of Atherosclerosis https://pubmed.ncbi.nlm.nih.gov/36545388/

Mary Garry, PhD

Publications

FOXK1 regulates Wnt signaling to promote cardiogenesis https://pubmed.ncbi.nlm.nih.gov/37036809/
ETV2 and VEZF1 interaction and regulation of the hematoendothelial lineage during embryogenesis https://pubmed.ncbi.nlm.nih.gov/36923254/

Grants

P01 HL160476-01 (Role Co-I) Mechanisms that govern cardiomyocyte proliferation and remuscularization following ventricular injury.

Paul Iaizzo, PhD FHRS FIEEE

Publications

A Multiscale Computational Model of Skeletal Muscle Electroporation Validated Using In Situ Porcine Experiments https://pubmed.ncbi.nlm.nih.gov/37022450/
Multimodal Comparisons of Results Achieved by Different Side Branch Ballooning Techniques for Bifurcation Provisional Stenting https://pubmed.ncbi.nlm.nih.gov/36943931/
Multimodal Imaging of a Culotte Bifurcation Procedure in the Left Main Coronary Artery of a Perfusion-Fixed Human Heart: Step-by-Step with Serial Micro-CT Analyses https://pubmed.ncbi.nlm.nih.gov/36939960/
Post-procedure micro-CT analyses of coronary artery stenting in left main vessels of reanimated and perfusion-fixed human hearts. https://pubmed.ncbi.nlm.nih.gov/36934270/
Preclinical research performed on reanimated/perfused swine kidneys: The Visible Kidney™ methodologies https://pubmed.ncbi.nlm.nih.gov/36878878/
Nerve Protection During Prostate Cryosurgery https://pubmed.ncbi.nlm.nih.gov/36088432/
Preclinical research performed on reanimated/perfused swine kidneys: The Visible Kidney™ methodologies https://pubmed.ncbi.nlm.nih.gov/36878878/
Post-procedure micro-CT analyses of coronary artery stenting in left main vessels of reanimated and perfusion-fixed human hearts https://pubmed.ncbi.nlm.nih.gov/36934270/

Other Noteworthy Items

The Visible Heart Laboratories said goodbye to Dr. Susana Arango, MD, Post-doctoral Associate in Anesthesiology (6/21 to 4/23 who worked collaboratively with Drs. Tjorvi Perry and Paul Iaizzo to create mixed reality teaching models to teach anatomy and cardiac function. She is starting anesthesia residency school at UMASS in the Fall of 2023.

Markus Meyer, MD, PhD

Publications

Effect of Personalized Accelerated Pacing on Quality of Life, Physical Activity, and Atrial Fibrillation in Patients With Preclinical and Overt Heart Failure With Preserved Ejection Fraction: The myPACE Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/36723919/

Other Noteworthy Items

Above publication: Randomized placebo controlled clinical trial of accelerated cardiac pacing (myPACE) in HFpEF. When compared to usual care this treatment approach resulted in marked improvements in quality of life, NT-pro BNP levels, patient activity and reduced the burden of atrial fibrillation. The clinical safety profile is favorable to suggest that clinical outcomes can be improved. This is the first targeted treatment approach in HFpEF and will overturn the "lower heart rate is better paradigm" in HFpEF that resulted in an overprescription of beta-blockers. At prescription rates of about 75-80% beta-blockers are the most commonly used medication class in HFpEF without any evidence that supports their use.

Rita Perlingeiro, PhD

Publications

Establishment of Skeletal Myogenic Progenitors from Non-Human Primate Induced Pluripotent Stem Cells https://pubmed.ncbi.nlm.nih.gov/37190056/

Grants

National Institutes of Health, NIAMS R01AR081882 – Targeting Dystroglycanopathies using Pluripotent-derived Myogenic Progenitors, Principal Investigator, 02/10/23 - 11/30/27

Other Noteworthy Items

Graduate student Bayardo Garay received the following awards: 1) Kathleen Moriarity Trainee Travel Award, April 14, 2023 2) J. Jacob Kaplan Research Award, April 3rd, 2023 3) Bacaner Research Award, April 3rd, 2023
Postdoctoral trainee Aline Yamashita was awarded the best poster presentation during the Greg Marzolf, Jr. Symposium, University of Minnesota, April 1, 2023

Kurt Prins, MD, PhD

Publications

Intermittent Fasting Activates AMP-Kinase to Restructure Right Ventricular Lipid Metabolism and Microtubules https://pubmed.ncbi.nlm.nih.gov/37034280/
ApoM Activates Autophagy and Suppresses Lyosomal Lethargy to Combat Doxorubicin Cardiomyopathy https://pubmed.ncbi.nlm.nih.gov/37034281/
Effect of Chronic Digoxin Use on Mortality and Heart Failure Hospitalization in Pulmonary Arterial Hypertension https://pubmed.ncbi.nlm.nih.gov/36892094/

Other Noteworthy Items

Sasha Prisco awarded AHA CDA Grant

Alena Talkachova, PhD

Publications

Editorial: Non-linear analysis and machine learning in cardiology https://pubmed.ncbi.nlm.nih.gov/37123256/
A Data-Driven Preprocessing Framework for Atrial Fibrillation Intracardiac Electrocardiogram Analysis https://pubmed.ncbi.nlm.nih.gov/36832698/

Grants

1R01HL165704-01A1, Role: co-I (PI: J. Dudley), Resolution of inflammation and atrial fibrillation

E.Kenneth Weir, MD

Publications

Pulmonary Arterial Hypertension Patients Have a Proinflammatory Gut Microbiome and Altered Circulating Microbial Metabolites https://pubmed.ncbi.nlm.nih.gov/36343281/

Beshay Zordoky, PhD

Publications

Metformin mitigates SASP secretion and LPS-triggered hyper-inflammation in Doxorubicin-induced senescent endothelial cells https://pubmed.ncbi.nlm.nih.gov/37168843/
Exposure to Doxorubicin Modulates the Cardiac Response to Isoproterenol in Male and Female Mice https://pubmed.ncbi.nlm.nih.gov/36986490/

Grants

Pediatric Cancer Survivorship Award Zordoky (PI) 03/01/2023 - 02/29/2024 Leveraging Senotherapeutics to Combat Doxorubicin-induced Immunosenescence Funder: UMN Childhood Cancer Research Fund
SURRGE Award Zordoky (PI) 03/01/2023 - 02/29/2024 Deciphering the Role of AMPK in Carfilzomib-induced Cardiovascular Dysfunction Funder: UMN College of Pharmacy

Other Noteworthy Items

Mohamed Dabour (2nd year PhD student) won 2nd place Best Poster Award at the Rho Chi Research Day, College of Pharmacy Poster title: Protective Effects of Canagliflozin against Carfilzomib-induced Endothelial Toxicity