Availability of data and materials
An inherent principle of publication is that others should be able to replicate and build upon the authors' published claims. Therefore, a condition of publication in a Nature journal is that authors are required to make materials, data and associated protocols available in a publicly accessible database (as detailed in the sections below on this page) or, where one does not exist, to readers promptly on request. Any restrictions on the availability of materials or information must be disclosed at the time of submission of the manuscript, and the methods section of the manuscript itself should include details of how materials and information may be obtained, including any restrictions that may apply. One preferred form of disclosure is a link from the methods section to a copy of the relevant Material Transfer Agreement (MTA) form, which is hosted as Supplementary Information on the journal's web site. Authors may charge a reasonable fee to cover the costs of producing and distributing materials. If materials are to be distributed by a for-profit company, this should be stated in the paper.
Nature journal editorials providing more detail for these policies:
Nature Cell Biology: Policy update (sharing materials)
Nature Chemical Biology: Molecular cross-fertilization
Nature Cell Biology: Sharing science
Nature: Illuminating the black box
Nature Cell Biology: Nothing to hide (data not shown)
Nature Genetics: Access to materials
Nature: Methods in full (comments on this methods format are welcome at Nautilus, the author blog).
Nature Methods: Social software (comments on this Nature Methods policy are welcome at Methagora, the Nature Methods blog).
Papers reporting protein or DNA sequences and molecular structures will not be accepted without an accession number to Genbank/EMBL/DDBJ, Protein DataBank, SWISS-PROT or other appropriate, identified, publicly available database in general use in the field that gives free access to researchers from the date of publication, as described in the Nature editorials listed below. All novel sequences or structure data must be made available to editors and referees either as Supplementary Information (five copies if provided on disk) or by an accession number to an appropriate publicly accessible database that can be accessed before publication. Please note that this policy includes even short stretches of novel sequence information such as epitopes, functional domains, genetic markers, or haplotypes. Short novel sequences must include surrounding sequence information to provide context.
The sequences of all RNAi, antisense and morpholino probes must be included in the paper or deposited in a public database, with the accession number quoted. When an unpublished library is included in the paper, at minimum the sequences of probes central to the conclusions of the paper must be presented.
Only indexed public repositories are acceptable for providing this type of information. Accession numbers are provided directly to authors by these databases on deposition of data, and must be included in the Nature journal paper before publication. All such deposited material must be freely available on and after the publication date.
Papers must state that atomic coordinates and structure factor files (or comparable NMR data) have been deposited in the Protein DataBank (or Nucleic Acids database or BioMagResBank, as appropriate), and must list the accession code(s). Accessibility must be designated "for immediate release on publication". Authors must provide atomic coordinates and structure-factor files upon request of peer-reviewers and editors for the purposes of evaluating the manuscript, if they are not already freely accessible in a publicly available and recognized database, via CD (five copies are required).
Proteomics databases recommended by Nature journals include the International Molecular Exchange consortium; PRIDE; IntAct; PeptideAtlas; Tranche; and the Global Proteome Machine Organization.
Nature journal editorials providing more detail for these policies:
Nature: New policy for structural data
Nature: Rules of genome access
Nature Medicine: Structural Integrity
Nature: Crystal Clear
Nature Cell Biology: Whither RNAi?
Nature Biotechnology: Democratizing proteomics data (Feedback and comments on this Nature Biotechnology policy are welcome at Nautilus, the author blog.)
Microarrays
Please see the MGED open letter specifying microarray standards. Authors submitting manuscripts containing microarray data must either provide accession number and URL or supply the data as Supplementary Information on CD at time of submission. The data must be MIAME-compliant and supplied in a form that is widely accessible, with the completed checklist also placed on the CD. If data are provided via CD at submission rather than as links to database entries, five copies are required so that they can be sent to peer-reviewers.
Nature journals require submission of microarray data to the GEO or ArrayExpress databases, with accession numbers at or before acceptance of the paper for publication.
Nature journal editorials providing more detail for these policies:
Nature: Microarray standards at last
Nature Immunology: Microarray policy
Nature Cell Biology: Microarray data standards (the third editorial on this web page)
Other supporting data
Any supporting data sets for which there is no public repository must be made available to referees at submission and any interested reader on and after the publication date from the authors directly, the author providing a URL to be used in the paper on publication.
Such material must be hosted on an accredited independent site (URL and accession numbers to be provided by the author), or sent to the Nature journal at submission, either uploaded via the journal's online submission service, or if the files are too large or in an unsuitable format for this purpose, on CD/DVD (five copies). Such material cannot solely be hosted on an author's personal or institutional web site.
After publication, readers who encounter a persistent refusal by the authors to comply with these guidelines should contact the chief editor of the Nature journal concerned, with "materials complaint" and publication reference of the article as part of the subject line. In cases where editors are unable to resolve a complaint, the journal reserves the right to refer the correspondence to the author's funding institution and/or to publish a statement of formal correction, linked to the publication, that readers have been unable to obtain necessary materials or reagents to replicate the findings.
Database deposition policy Science supports the efforts of databases that aggregate published data for the use of the scientific community. Therefore, before publication, large data sets (including microarray data, protein or DNA sequences, and atomic coordinates or electron microscopy maps for macromolecular structures) must be deposited in an approved database and an accession number provided for inclusion in the published paper.
- Molecular structure data. Atomic coordinates and structure factor files from x-ray structural studies or an ensemble of atomic coordinates from NMR structural studies must be deposited and released at the time of publication. Three-dimensional maps derived by electron microscopy and coordinate data derived from these maps must also be deposited. Approved databases are the Worldwide Protein Data Bank [through the Research Collaboratory for Structural Bioinformatics, Macromolecular Structure Database (MSD EMBL-EBI), or Protein Data Bank Japan], BioMag Res Bank, and Electron Microscopy Data Bank (MSD-EBI), and for synthetic molecules, the Cambridge Crystallographic Data Centre.
- DNA and protein sequences. Approved databases are GenBank or other members of the International Nucleotide Sequence Database Collaboration (EMBL or DDBJ) and SWISS-PROT.
- Microarray data. Data should be presented in MIAME-compliant standard format. Approved databases are Gene Expression Omnibus and ArrayExpress.
- Large data sets with no appropriate approved repository must be housed as supporting online material at Science, or when this is not possible, on the author's web site, provided a copy of the data is held in escrow at Science to ensure availability to readers. For answers to questions regarding allowable supporting online material, please see our guidelines; further questions can be directed to Stewart Wills, Online Editor.
Data availability After publication, all data necessary to understand, assess, and extend the conclusions of the manuscript must be available to any reader of Science. We recognize that discipline-specific conventions or special circumstances may occasionally apply, and we will consider these in negotiating compliance with requests. Any concerns about your ability to meet Science's requirements must be disclosed and discussed with an editor. For further information about accessibility of data and materials, see the following resources.
- Cech, T. R. (2003), Sharing Publication-Related Data and Materials: Responsibilities of Authorship in the Life Sciences.
- American Psychological Association, Responsible Conduct of Research: Data Sharing and Data Archiving.
- National Science Foundation Policy on Data Sharing [PDF].
MICROARRAY DATA
All authors must comply with the 'Minimal Information About a Microarray Experiment' (MIAME) guidelines published by the Microarray Gene Expression Data Society, which can be found at http://www.mged.org/Workgroups/MIAME/miame_checklist.html. HMG also requires submission of microarray data to the GEO (http://www.ncbi.nlm.nih.gov/geo/) or ArrayExpress (http://www.ebi.ac.uk/arrayexpress/) databases, with accession numbers at or before acceptance for publication.
ACCESSION NUMBERS
Authors should be aware that all new sequence information, including that which extends a previously determined sequence already present in the database (and which already has an accession number), must be submitted to any of the three major collaborative databases - DDBJ (http://www.ddbj.nig.ac.jp), EMBL (http://www.ebi.ac.uk), GenBank (http://www.ncbi.nlm.nih.gov) - for a new accession number. It is only necessary to submit to one database, without regard to where the sequence data will be published. Data are exchanged between DDBJ, EMBL and GenBank on a daily basis. This number must be provided before acceptance of the manuscript. Accession numbers from the major collaborative databases should be cited in the text as (GenBank accession no. AF149731). Other databases should be identified where used. Accession numbers should be listed on the title page.
For all submissions, authors must clearly provide detail, data, and software to ensure readers' ability to reproduce the models, methods, and results.
Accession Numbers
All appropriate datasets, images, and information should be deposited in public resources. Please provide the relevant accession numbers (and version numbers, if appropriate). Suggested databases include, but are not limited to:
- ArrayExpress
- BioModels Database
- Database of Interacting Proteins
- DNA Data Bank of Japan [DDBJ]
- EMBL Nucleotide Sequence Database
- GenBank
- Gene Expression Omnibus [GEO]
- Protein Data Bank
- UniProtKB/Swiss-Prot
In addition, as much as possible, please provide accession numbers or identifiers for all entities such as genes, proteins, mutants, diseases, etc., for which there is an entry in a public database, for example:
- Ensembl
- Entrez Gene
- FlyBase
- InterPro
- Mouse Genome Database (MGD)
- Online Mendelian Inheritance in Man (OMIM)
Providing accession numbers allows linking to and from established databases and integrates your article with a broader collection of scientific information. Please list all accession numbers directly after the Supporting Information section.
Microarray Studies
Data obtained by microarray must be submitted to a repository such as the Gene Expression Omnibus or ArrayExpress prior to submission. The raw and transformed data sets for each microarray experiment must be provided through the repository, and the Accession Number for each experiment or series provided in the Methods section. If the data are password-protected, the user name and password must be provided in the cover letter and the Methods section of the manuscript at the time of submission. A criterion of publication is full access to the relevant data sets through a publicly accessible repository.
None
BMC GenomicsSubmission of a manuscript to BMC Bioinformatics implies that readily reproducible materials described in the manuscript, including all relevant raw data, will be freely available to any scientist wishing to use them for non-commercial purposes. Nucleic acid sequences, protein sequences, and atomic coordinates should be deposited in an appropriate database in time for the accession number to be included in the published article. In computational studies where the sequence information is unacceptable for inclusion in databases because of lack of experimental validation, the sequences must be published as an additional file with the article.
Any 'in press' articles cited within the references and necessary for the reviewers' assessment of the manuscript should be made available if requested by the editorial office.
Nucleotide sequences
Nucleotide sequences can be deposited with the DNA Data Bank of Japan (DDBJ), European Molecular Biology Laboratory (EMBL/EBI) Nucleotide Sequence Database, or GenBank (National Center for Biotechnology Information).Protein sequences
Protein sequences can be deposited with SwissProt or the Protein Information Resource (PIR).Structures
Protein structures can be deposited with one of the members of the Worldwide Protein Data Bank. Nucleic Acids structures can be deposited with the Nucleic Acid Database at Rutgers. Crystal structures of organic compounds can be deposited with the Cambridge Crystallographic Data Centre.Chemical structures and assays
Structures of chemical substances can be deposited with PubChem Substance. Bioactivity screens of chemical substances can be deposited with PubChem BioAssay.Microarray data
Where appropriate, authors should adhere to the standards proposed by the Microarray Gene Expression Data Society and must deposit microarray data in one of the public repositories, such as ArrayExpress, Gene Expression Omnibus (GEO) or the Center for Information Biology Gene Expression Database (CIBEX).Computional modeling
We encourage authors to prepare models of biochemical reaction networks using the Systems Biology Markup Language and to deposit the model with the BioModels database, as well as submitting it as an additional file with the manuscript.Plasmids
We encourage authors to deposit copies of their plasmids as DNA or bacterial stocks with Addgene, a non-profit repository, or PlasmID, the Plasmid Information Database at Harvard.
Submission of a manuscript to BMC Genomics implies that readily reproducible materials described in the manuscript, including all relevant raw data, will be freely available to any scientist wishing to use them for non-commercial purposes. Nucleic acid sequences, protein sequences, and atomic coordinates should be deposited in an appropriate database in time for the accession number to be included in the published article. In computational studies where the sequence information is unacceptable for inclusion in databases because of lack of experimental validation, the sequences must be published as an additional file with the article.
Any 'in press' articles cited within the references and necessary for the reviewers' assessment of the manuscript should be made available if requested by the editorial office.
Nucleotide sequences
Nucleotide sequences can be deposited with the DNA Data Bank of Japan (DDBJ), European Molecular Biology Laboratory (EMBL/EBI) Nucleotide Sequence Database, or GenBank (National Center for Biotechnology Information).
Protein sequences
Protein sequences can be deposited with SwissProt or the Protein Information Resource (PIR).
Structures
Protein structures can be deposited with one of the members of the Worldwide Protein Data Bank. Nucleic Acids structures can be deposited with the Nucleic Acid Database at Rutgers. Crystal structures of organic compounds can be deposited with the Cambridge Crystallographic Data Centre.
Chemical structures and assays
Structures of chemical substances can be deposited with PubChem Substance. Bioactivity screens of chemical substances can be deposited with PubChem BioAssay.
Microarray data
Where appropriate, authors should adhere to the standards proposed by the Microarray Gene Expression Data Society and must deposit microarray data in one of the public repositories, such as ArrayExpress, Gene Expression Omnibus (GEO) or the Center for Information Biology Gene Expression Database (CIBEX).
Computional modeling
We encourage authors to prepare models of biochemical reaction networks using the Systems Biology Markup Language and to deposit the model with the BioModels database, as well as submitting it as an additional file with the manuscript.
Plasmids
We encourage authors to deposit copies of their plasmids as DNA or bacterial stocks with Addgene, a non-profit repository, or PlasmID, the Plasmid Information Database at Harvard.
| 1 | 1 | freely available to scientists for non-commercial purposes | 1 | 1 | Should adhere to MGED standards | 1 | 1 | CIBEX | lots | ||||
Software
If the manuscript describes new software tools or the implementation of novel algorithms the software must be freely available to non-commercial users at the time of submission. Availability must be clearly stated in the article. Authors must also ensure that the software is available for a full TWO YEARS following publication. The editors of Bioinformatics encourage authors to make their source code available and, if possible, to provide access through an open source license (see www.opensource.org for examples). Authors should make every effort to use URLs that will remain stable.Supporting Data
All data on which the conclusions given in the publication are based must be publicly available. Bioinformatics fully supports the recommendations of the National Academies regarding data sharing (see Board on Life Sciences, Sharing Publication-Related Data and Materials: Responsibilities of Authorship in the Life Sciences. Available at www.nap.edu/books/0309088593/html). If the analysis is based on new datasets, authors are encouraged to submit these to appropriate public repositories. In particular, microarray data should be submitted to one of the recognized public repositories in a MIAME compliant way (see C. A. Ball et al., Submission of Microarray Data to Public Repositories. PLoS Biology, 2, e317). In any event, all data should be made available to the journal for the purpose of peer review. If your manuscript describes a three-dimensional model of a protein that has been manually built, you should deposit it in the PMDB database (http://www.caspur.it/PMDB, see also NAR 34, 306-309). The database will return a unique identifier which you can include in your manuscript, thereby allowing readers to have access to your model.
Clinical Cancer Research
http://clincancerres.aacrjournals.org/misc/ifora.shtmlAvailability of Materials. It is understood that by publishing any work in Clinical Cancer Research the authors agree to make freely available to other academic researchers any of the cells, clones of cells or DNA or antibodies, etc. that were used in the research reported and that are not available from commercial suppliers. The publication of articles including new genes, proteins or crystallographic structures is contingent on deposition of the accession number and/or structural coordinates in a publicly accessible database. The reporting requirements extend to the chemical structures of drugs, as well as sequences of oligonucleotides used in antisense strategies and RNA. In addition, AACR journals require the disclosure of chemical structures of any unpublished synthetic, low molecular weight (<1,000 g/mol) chemical compounds used as part of the described research (including clinical studies in humans). These requirements are subject to amendment as the need for disclosure changes with evolving technologies. Also, authors may be required to make primary data available to the Editor-in-Chief in cases of dispute.
Depositing Data in Public Databases. The AACR requires that authors submitting manuscripts describing microarray data be prepared to supply peer reviewers with the data in a format that conforms to the Minimum Information About a Microarray Gene Experiment (MIAME) guidelines of the Microarray Gene Expression Data society (MGED). These guidelines include a checklist of information to be included with each new microarray submission; the checklist is available online (http://www.mged.org/Workgroups/MIAME/miame_checklist.html). Authors will also be required to deposit the data with either of two public repositories: GEO (www.ncbi.nlm.nih.gov/geo/) or Array Express (www.ebi.ac.uk/arrayexpress) and to have the accession numbers available to be published in the article.
Large data sets of peripheral significance to the main thesis of the investigation will not be published in Clinical Cancer Research but may be posted in the Data Supplements section of Clinical Cancer Research online. The manuscript should contain a footnote that indicates how this ancillary material can be obtained. Contact the AACR Publications Department [phone: (215) 440-9300] for more information. Supplementary data should be submitted for review with the manuscript. See section “Online Submission” for additional information.
Authors of manuscripts with new nucleotide or amino acids sequences are asked to deposit the sequence information with GenBank (National Center for Biotechnology Information, Building 38A, Rm. 8N-803, 8600 Rockville Pike, Bethesda, MD 20894; phone: (301) 496-2475; fax: (301) 480-9241; e-mail for information: nfo@ncbi.nlm.nih.gov; e-mail for submission: b-sub@ncbi.nlm.nih.gov.
Authors outside of the United States may elect to deposit sequence information in the European Molecular Biology Laboratory (EMBL) database (e-mail: datasubs@ebi.ac.uk) or the DNA Databank of Japan (e-mail: datasubs@ebi.ac.uk). The accession numbers for deposited sequences will be published with the article.
Availability of materials
The Editors are prepared to deny further publication rights in the Journal to authors unwilling to abide by these principles.
Deposition of sequence and structural data
Sequence information, co-ordinates used to create molecular models
described in a manuscript, and structural data must be submitted in
electronic form, prior to acceptance, to the appropriate database for
release no later than the date of publication of the corresponding
article in the Journal. Deposition numbers and/or accession numbers
provided by the database should be included in the manuscript and
entered into the relevant boxes during online submission or
communicated to the Executive Editor handling the manuscript as soon as
received. In cases where there may be no appropriate database, atomic
co-ordinates may be included in the publication as supplementary
material. Manuscripts will not be published until the Journal is in
receipt of the deposition number.
For papers reporting novel nucleic acid sequences
Nucleic acid sequence information must be deposited with one of
the three major collaborative databases (EMBL/GenBank/DDBJ). For
sequences obtained from a public or private web site, it is the
author's responsibility to ensure that any sequence used within the
manuscript is deposited before publication. It is necessary to submit
sequences to one database only since data are exchanged between EMBL,
GenBank and DDBJ on a daily basis. New sequence names and their
accession numbers should be listed at the beginning of the Materials
and Methods section to aid searches by readers. In order to allow new
methods of data search, NAR encourages authors to cite GenBank accession numbers when referring to established sequences within their manuscript. Contact details for submission to databases.
For papers reporting novel three-dimensional structures
Atomic co-ordinates and the related experimental data (structure
factor amplitudes/intensities and/or NMR restraints) must be deposited
with a database. Authors must agree to release the atomic coordinates
and experimental data when the associated article is published.
The Cambridge Crystallographic Data Centre (CCDC) is appropriate
for deposition of data on nucleosides, nucleotides and other small
molecules.
A member site of the Worldwide Protein Data Bank (www.wwpdb.org):
RCSB PDB (www.pdb.org), MSD-EBI (www.ebi.ac.uk/msd), PDBj
(www.pdbj.org), or BMRB (www.bmrb.wisc.edu) is appropriate for
deposition of data on proteins determined by X-ray crystallography and
for all macromolecules determined by NMR methods.
The Nucleic Acid Database (NDB) is appropriate for atomic
co-ordinate and structure factor data for crystal structures of nucleic
acids. Contact details for submission to databases.
Contact details for submission to databases.
For papers reporting novel protein sequences
Protein sequences, which have been determined by direct sequencing
of the protein, must be submitted to UniProt (i.e. TrEMBL, Swiss-Prot
and PIR) using the interactive submission tool SPIN. Please note that
they do not provide accession numbers, IN ADVANCE, for protein
sequences that are the result of translation of nucleic acid sequences.
These translations will forwarded automatically from the nucleotide
sequence databases (EMBL/GebBank/DDBJ) and assigned UniProt accession
numbers on incorporation into UniProt. Results from characterization
experiments should also be submitted to UniProt: for novel sequences,
these should be included with the sequence submission. Existing UniProt
entries should also be updated. This can include information such as
function, subcellular location, subunit, etc. Contact details for submission to databases.
Microarray data All authors must comply with the 'Minimal Information About a Microarray Experiment' (MIAME) guidelines published by the Microarray Gene Expression Data Society, which can be found at http://www.mged.org/Workgroups/MIAME/miame_checklist.html. NAR also requires submission of microarray data to the GEO (http://www.ncbi.nlm.nih.gov/geo/) or ArrayExpress (http://www.ebi.ac.uk/arrayexpress/) databases, with accession numbers at or before acceptance for publication.
All authors of articles submitted to APS journals should submit their relevant data to all appropriate data repositories, such as the National Center for Biotechnology Information (NCBI) and the European Bioinformatics Institute (EBI).
Section Contents
MIAME Standard for Microarray Data
HUGO Gene Nomenclature
The American Physiological Society has adopted the microarray data standard developed by the Microarray Gene Expression Data society (MGED) and requests that all authors using microarray data analysis in their research submit a complete data set to one of three databases prior to manuscripts submission: the NCBI Gene Expression Omnibus (GEO); the EMBL-EBI ArrayExpress repository; or the Center for Information Biology Gene Expression (CIBEX) database.
Rationale
Within a short time span, microarrays have become an important, commonly used tool in molecular genetics and physiology research. For microarray analysis of gene expression to have any long-term impact, it is crucial that the issue of reproducibility be adequately addressed. In addition, since microarray analytic standards are certain to change, it is crucial that authors identify the nature of the experimental conditions prevalent at the time of their research. If today’s research is to be relevant tomorrow, the core elements that are immune to obsolescence must be made clear. The APS Journals are adopting the MIAME standards to ensure that what is cutting edge today is not obsolete few years later.
The outline below indicates the general nature of the information we expect you to provide, but we request that you follow the specific guidelines provided at the MGED web site.
Summary of requested information
Experimental design detailing the parameters of the microarray hybridization experiment including the number of hybridizations, whether dye switching was utilized, and the use of any reference samples.
Details of the samples including the tissue from which nucleic acids were extracted, the materials and methods used for extraction, and the labeling protocol.
Hybridization procedures.
Measurement data and specifications in the form of tab-delimited tables or Excel spreadsheets. As summarized in the published guidelines to the format, “The first could contain the ‘raw’ output of the image analysis software (spot quantitation matrix), the second could contain the ‘processed’ data following normalization and transformation (gene expression data matrix), and if one is produced, the final table could contain ‘summary’ data that was ultimately used in the analysis, such as the subset of differentially expressed genes identified or gene clusters.”
Array design including complete details of the location and identification of each feature on the array, whether commercial or noncommercial, information on the design of the array, and the spotting protocols.
How to ensure compliance with the MIAME standard
On the MGED website, read the pertinent information and follow the guidelines provided before preparing your microarray information for deposit.
Deposit your microarray data in the GEO data base, following the required guidelines.
Provide the accession numbers for your GEO-deposited data in the Methods section of your paper to make it available during the peer review of your submitted paper.
Also, provide the set of login credentials (username and password) that will let referees access the data set during review, if it is set up as a private resource.
Work published in the APS Journals must necessarily be independently verifiable. Authors describing results derived from the use of antibodies, recombinant plasmids and cloned DNAs, mutant cell lines or viruses, and other similarly unique materials are expected to make such materials available to qualified investigators on request. Authors should also submit published nucleic acid/amino acid sequences to a widely accessible data bank. Sequence data for the United Protein Database (UniProt) should be submitted directly to UniProt using SPIN, a new web-based tool for submitting protein sequences. Also, for other special types of submissions (e.g., genomes, bulk submissions), additional submission protocols are available from the following organizations:
Plasmids: Authors are encouraged to deposit plasmid constructs
in a public repository such as Addgene
(www.addgene.org).
Characterization of Chemical Compounds: Authors must provide sufficient information to establish the identity of a new compound and its purity. Sufficient experimental details must be included to allow other researchers to reproduce the synthesis. Characterization data and experimental details must be included either in the text or the Supporting Information.
Protein and Nucleic Acid Sequences: Authors must deposit data in a publicly available database such GenBank/EMBL/DNA Data Bank of Japan or Swiss-Prot.
Structural Studies: Authors of papers describing new structure determinations must submit to the Protein Data Bank at the Research Collaboratory for Structural Bioinformatics or its equivalent all structural data required to validate the discussion, including x-ray amplitudes, structure factor files, and the derived atomic coordinates. For nuclear magnetic resonance structures, data deposited should include resonance assignments and all restraints used in structure determination and the derived atomic coordinates for both an individual structure and a family of acceptable structures. Articles must include literature references for all coordinate data sets as well as data set identification. Authors must agree to release the coordinates when the article is published.
Functional Magnetic Resonance Imaging (fMRI) Studies: Authors should deposit data with the fMRI Data Center or other suitable public repositories.
Genomic and Proteomic Studies: Authors of papers that include genomic, proteomic, or other high-throughput data are required to submit their data to the NCBI gene expression and hybridization array data repository (GEO, www.ncbi.nlm.nih.gov/geo) or equivalent publicly accessible database and must provide the accession number. Access to the information in the database must be available at the time of publication. Submitted data should follow the MIAME checklist (for more information, see www.mged.org/Workgroups/MIAME/miame_checklist.html).
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