The Interpretations “How to use” series will cover a number of diverse topics based around tests or investigations. The core aim is to take a paediatrician from the point of little or no knowledge of the technique, and give them the information they need to intelligently assess whether or not they should be using the test, and if they do use it, how it should be used.
In order for the reader to develop familiarity with the series, a fairly standardised approach is required.
Introduction of 200 to 300 words, placing the test and its current use in context.
The physiological or even physical basis of the technique.
Technological background. Part of this might be too esoteric or too theory based to be useful to reference, or may even be subject to patent. An example of this would be http://bmj.com/cgi/content/full/325/7362/484 BMJ 2002;325:484 ( 31 August ). This paper simply examines what the test actually does. It is interesting, but limited in clinical application; this paper tells you very little about when to do a DEXA, which is what the next section is about.
Indications, or validation – with evidence base in children. This would be formulated as one or more clinical questions: "In children with suspected X [patients], what are the characteristics [outcome] of OurTest". This would be quantified using likelihood ratios and specimen pre- and post-test probabilities – or the absence of any such data made clear. An important principle of this section is to emphasise when the test is actually useless.
Limitations – where this has not been clearly covered in the preceding part.
A section for the “holes” – ie the bits that we don’t quite get yet, or for which there is no actual evidence – a sort of “research registrars look here for projects” bit.
Lastly a “clinical bottom line”; a series of bullet points (no more than 5) for a reader to assess and assimilate.
The article should be between 2000 and 3000 words, not including references. Statements of fact should be referenced; statements of opinion should be made clear.
After submission, the paper will be reviewed by the handling editor to check for adherence to the brief, and also by an expert in the field.
Ian Wacogne